Premium
Interferon as an adjuvant treatment for genital condyloma acuminatum
Author(s) -
Klutke J.J.,
Bergman A.
Publication year - 1995
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(95)02339-e
Subject(s) - medicine , adjuvant , colposcopy , interferon , condyloma acuminatum , fluorouracil , adjuvant therapy , alpha interferon , surgery , sex organ , gastroenterology , hpv infection , dermatology , chemotherapy , human papillomavirus , immunology , cancer , cervical cancer , biology , genetics
Objective: To evaluate the effect of alpha‐interferon as an adjuvant to laser or fluorouracil treatment in patients with recurrent genital human papillomavirus (HPV) infection. Methods: Sixty‐two females and 21 males were treated for recurrent HPV infection, with either fluorouracil (Efudex 5%) cream or laser ablation of the lesions. Half of the patients were then randomly treated with adjuvant alpha‐interferon, to the lesions for patients treated with fluorouracil, or beneath areas previously treated by laser, once a week, for 8 weeks. The other half of the patients did not receive interferon adjuvant. Evaluation of both groups was done using colposcopy and acetic acid, to assess recurrence rates up to 1 year after treatment. Results: Of the 83 patients followed for 1 year, colposcopy revealed recurrent anogenital lesions in 3 of 45 receiving interferon, compared with 9 of 38 patients treated without adjuvant interferon. Conclusion: Interferon is effective as adjuvant treatment in controlling the recurrence of genital HPV.