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Malignant mixed Müllerian tumors of the uterus
Author(s) -
To W.W.K.,
Ngan H.Y.S.
Publication year - 1994
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(94)90459-6
Subject(s) - medicine , müllerian mimicry , uterus , gynecology , pathology
Objective: To review the prognostic factors of Chinese women with mixed Müllerian tumors of the uterus. Method: A retrospective review of 21 cases of malignant mixed Müllerian tumors of the uterus treated during the 10‐year period from 1980 to 1990. Results: All patients except one were postmenopausal. The incidence of previous pelvic irradiation was 9.5%. The most common presenting symptom was abnormal vaginal bleeding. One‐third of patients yielded an abnormal cervical smear. Treatment included surgery, chemotherapy and radiotherapy in the majority of patients. Prognosis was poor with only three long‐term survivors, all with stage‐I homologous tumors with superficial myometrial invasion. The survival rate for stage‐I and ‐II disease at 2 years was 50% and for more advanced disease extending beyond the uterus was 0%. The survival rate for all stages at 5 years was 14.3%, and the cumulative probability of survival at 5 years was 0.165. Conclusion: The most important prognostic factors appear to be the extent of tumor involvement at the time of diagnosis and the depth of myometrial invasion.