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Effect of hormone replacement therapy on bone and lipid metabolism in women oophorectomized for the treatment of gynecologic malignancies
Author(s) -
Yasuda M.,
Kurabayashi T.,
Yamamoto Y.,
Fujimaki T.,
Oda K.,
Tanaka K.
Publication year - 1994
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(94)90356-5
Subject(s) - medicine , hormone replacement therapy (female to male) , bone remodeling , oophorectomy , endocrinology , osteopenia , lipid metabolism , bone mineral , lipoprotein , lipid profile , estrogen , osteoporosis , cholesterol , surgery , testosterone (patch) , hysterectomy
Objective: Our purpose was to evaluate the effects of hormone replacement therapy (HRT) on bone and lipid metabolism in women oophorectomized for the treatment of gynecologic malignancies. Methods: Bone mineral density (BMD), bone metabolic markers, sex hormones and lipoproteins were measured in three groups of age‐ and body mass‐matched subjects. The subjects consisted of HRT(+) patients, i.e. those given HRT after oophorectomy (n = 39), HRT(−) patients, who received no HRT (n = 15), and controls comprising premenopausal women with no history of oophorectomy (n = 36). Results: BMD decreased significantly in the HRT(−) patients, but no decrease in BMD was observed in the controls or HRT(+) patients. HRT was effective in preventing bone loss by reducing high‐turnover osteopenia. HRT reversed the negative trends in lipoprotein profiles by lowering low‐density lipoprotein cholesterol and increasing high‐density lipoprotein cholesterol. There were no serious side effects or recurrences among the HRT(+) patients. Conclusion: HRT appeared to have beneficial effects on bone and lipid metabolism in oophorectomized patients treated for gynecologic malignancies.