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Management of human papilloma virus vulvo‐perineal infection with systemic β‐interferon and thymostimulin in HIV‐positive patients
Author(s) -
Frega A.,
Renzi F.,
Stentella P.,
Pachi A.
Publication year - 1994
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(94)90175-9
Subject(s) - medicine , human immunodeficiency virus (hiv) , human papilloma virus , immunology , virology , virus , cancer , cervical cancer
OBJECTIVES: To evaluate the effect of a combined therapy based on β‐interferon and thymostimulin in HIV‐seropositive women with florid vulvoperineal condylomatosis. METHODS: Nineteen HIV‐seropositive women affected by HPV florid vulvoperineal infection were studied. Their ages ranged from 19 to 32 years (mean = 26); all were smokers; 11 (57.89%) were intravenous drug users with a mean period of drug addiction of 5 years. No patient was on AZT therapy. All patients underwent a combined medical therapy based on β‐interferon administration with doses of 3 000 000 IU i.m. daily for 7 days and subsequently on alternate days for 2 weeks associated with the administration of 70 mg i.m. of thymostimulin per day on alternate days for 30 days. RESULTS: Seven (36.84%) patients showed complete recovery at the end of follow‐up; 5 (26.31%) patients showed partial recovery and 7 (36.84%) did not respond to therapy. CONCLUSION: A pro‐host immunotherapy seems to be indicated in patients affected by immunodeficiency syndrome.