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Serum CA‐125 in the diagnosis of acute pelvic inflammatory disease
Author(s) -
Mozas J.,
Castilla J.A.,
Jimena P.,
Gil T.,
Acebal M.,
Herruzo A.J.
Publication year - 1994
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(94)90023-x
Subject(s) - laparoscopy , pelvic inflammatory disease , medicine , laparotomy , radioimmunoassay , gastroenterology , receiver operating characteristic , pelvic pain , urology , surgery
OBJECTIVES: To determine the efficiency of different tumor markers (CA‐125, carcinoembrionic antigen, CA‐15.3, CA‐19.9) and insulin‐like growth factor I (IGF‐I) measurements as a screening procedure for acute pelvic inflammatory disease (PID). METHODS: Peripheral blood samples were obtained at the time of laparoscopy from three groups of women: (1) 50 women who underwent laparoscopic tubal ligation and had no evidence of PID (control group); (2) 20 women admitted because of suspected PID, but at laparoscopy or laparotomy had no signs of PID; (3) 20 patients who underwent acute PID diagnosed by laparoscopy. Serum levels of: CA‐125, carcinoembrionic antigen, CA‐15.3 and CA‐19.9, and plasma IGF‐I, were measured by radioimmunoassay. RESULTS: No differences were observed in the levels of CA‐15.3, CA‐19.9, carcinoembrionic antigen and IGF‐I between the three groups studied. Serum levels of CA‐125 were significantly higher in patients who had PID. Analysis of receiver operating characteristic curves showed that only CA‐125 was useful in diagnosis of acute PID. The cut‐off level was 43.7 U/ml for CA‐125. CONCLUSIONS: Measurement of serum CA‐125 concentrations is recommended as a useful test for acute PID in patients undergoing laparoscopy for pelvic pain.