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Evaluation of calcium‐antagonist (Nifedipine) in the treatment of pre‐eclampsia
Author(s) -
Ismail A.A.A.,
Medhat I.,
Tawfic T.A.S.,
Kholeif A.
Publication year - 1993
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(93)90770-w
Subject(s) - nifedipine , medicine , eclampsia , blood pressure , umbilical artery , antagonist , anesthesia , placebo , creatinine , calcium , pregnancy , gestation , receptor , alternative medicine , pathology , biology , genetics
The therapeutic effect of the calcium antagonist; Nifedipine was assessed in 30 patients with pre‐eclampsia. Cases were randomly allocated into two groups; a study group (n = 20) who received Nifedipine capsules (20 mg every 8 h for 7 days) and a control group (n = 10) who received placebo capsules with the same regimen. After Nifedipine administration, there was a significant decrease in blood pressure, serum urea and creatinine and 24 h urinary proteins. No significant difference was found in FHR and S/D ratio of the umbilical artery between study and control groups or between initial values and after Nifedipine administration. Preliminary results indicated that Nifedipine decreased blood pressure and improved kidney functions without affecting the umbilical artery blood flow in cases of preeclampsia.