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Insulin responses following glucose administration in menstruating women
Author(s) -
Ezenwaka E.C.,
Akanji A.O.,
Adejuwon C.A.,
Abbiyesuku F.M.,
Akinlade K.S.
Publication year - 1993
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(93)90630-f
Subject(s) - luteal phase , menstrual cycle , follicular phase , endocrinology , insulin , medicine , insulin resistance , pancreatic hormone , hormone
OBJECTIVE: The aim of the study was to investigate changes in insulin sensitivity during the menstrual cycle, in a group of regularly menstruating black African women. METHOD: Insulin responses to intravenous glucose (300 mg/kg) were assessed, for up to 3 h, in 3 groups of age‐ and body mass‐matched nonobese sedentary Nigerian women: Group A, 7 women in the menstrual follicular phase; Group B, 7 women in the menstrual luteal phase; C, 7 men. RESULT: Women in the menstrual luteal phase had the greatest integrated firstphase insulin response and insulin/glucose ratios, much higher than the similar values for these variables obtained in other groups. This suggests that the menstrual luteal phase is associated with relative insulin resistance. CONCLUSION: Black African women in the menstrual luteal phase demonstrate an exaggerated insulin response to an acute glucose load and are thus relatively insulin‐insensitive. This confirms previous observations in Caucasians.