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Tinidazole prophylaxis in elective abdominal hysterectomy
Author(s) -
Dhar K.K.,
Dhall G.I.,
Ayyagari A.
Publication year - 1993
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(93)90624-6
Subject(s) - medicine , tinidazole , abdominal hysterectomy , hysterectomy , antibiotic prophylaxis , incidence (geometry) , placebo , abdominal surgery , surgery , randomized controlled trial , antibiotics , anesthesia , metronidazole , physics , alternative medicine , optics , pathology , microbiology and biotechnology , biology
OBJECTIVE: To determine whether a single dose (2 g) of tinidazole before abdominal hysterectomy could reduce the incidence of postoperative infection. METHOD: A randomized double‐blind placebo‐controlled study was undertaken with a single oral dose (2 g) of tinidazole, 12 h before surgery, in 100 patients undergoing abdominal hysterectomy for various benign diseases. Other antibiotic use was withheld until there was no postoperative infection. RESULT: A significant reduction (P < 0.05) of infectious morbidity (28% vs. 8%) as well as a decrease in additional antibiotic use (P < 0.01) and duration of hospital stay (P < 0.001) was observed. Febrile morbidity was also reduced from 36% to 14% (P < 0.05). Tinidazole was tolerated well by all the patients. CONCLUSION: Tinidazole prophylaxis (2 g oral dose) is considered to be a simple, safe and effective way to reduce postoperative infection in abdominal hysterectomy.