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Pregnancy after liver transplantation
Author(s) -
Baruch Y.,
Weiner Z.,
Enat R.,
Ronen N.,
Blumenfeld Z.
Publication year - 1993
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(93)90556-c
Subject(s) - medicine , azathioprine , gestation , prednisone , pregnancy , immunosuppression , liver transplantation , liver disease , cirrhosis , transplantation , surgery , gastroenterology , disease , biology , genetics
Abstract Two patients who became pregnant after liver transplantation for end‐stage liver disease were carefully monitored using pulsed Doppler waveform measurements. One patient with Wilson's disease, on triple immunosuppressive therapy including prednisone, azathioprine and low‐dose cyclosporin A, delivered a healthy girl weighing 2650 g after 38 weeks' gestation. The other patient, with HBV‐related postnecrotic cirrhosis, became pregnant less than 3 months postoperatively, under triple therapy, after being amenorrheic for 6 years. Episodes of elevation in liver enzymes were noted, and severe osteoporosis with low back pain developed. A healthy boy weighing 2975 g was born at 35 weeks' gestation. Our cases add to previous reports of successful pregnancies under cyclosporin A immunosuppression.