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Human leukocyte antigen in hydatidiform mole
Author(s) -
Souka A.R.,
Kholeif A.,
Zaki S.,
Rocca M.,
Ghanem I.
Publication year - 1993
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(93)90552-8
Subject(s) - human leukocyte antigen , mole , medicine , locus (genetics) , antigen , partial hydatidiform mole , immunology , obstetrics , pregnancy , gene , genetics , fetus , biology , placenta
OBJECTIVE: To find any possible association between human leukocyte antigen (HLA) as a genetic marker and the development of hydatidiform mole (HM). METHOD: The lymphocyte microtoxicity technique was used to study the HLA antigens in 3 groups: 18 women with hydatidiform mole and their husbands (study group), 300 normal women (first control group), and 20 normal pregnant women and their husbands (second control group). RESULT: Hydatidiform mole is more frequent in women having HLA A 1 . The disease is more common in couples with partial compatibility of the B locus. CONCLUSION: HM occurs more frequently in women with certain HLA antigens and when the husband and wife have partial compatibility at the B locus.