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Polymerase chain reaction analysis of human papillomavirus in adenocarcinoma and adenosquamous carcinoma of the uterine cervix
Author(s) -
Matsuo N.,
Iwasaka T.,
Hayashi Y.,
Hara K.,
Mvula M.,
Sugimori H.
Publication year - 1993
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(93)90551-7
Subject(s) - adenosquamous carcinoma , medicine , adenocarcinoma , polymerase chain reaction , cervix , human papillomavirus , uterine cervix , carcinoma , squamous carcinoma , pathology , oncology , cancer research , cancer , biology , gene , genetics
Thirty‐two cervical adenocarcinomas and adenosquamous carcinomas were examined to search for human papillomaviruses (HPVs) using the polymerase chain reaction system. Human papillomavirus type 16 (HPV16) and type 18 (HPV18) deoxyribonucleic acid was detected in 22% and 16% of these carcinomas, respectively. HPV16 was the most common type in both adenocarcinoma and adenosquamous carcinoma, and the mean age of the HPV negative patients was significantly higher than that of HP V positive patients. There may be an association between HPVs and the development of certain adenocarcinomas and adenosquamous carcinomas of the cervix.