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Detection of human papillomavirus types 16 and 18 in the exfoliated cervical cells using the polymerase chain reaction
Author(s) -
Nakazawa A.,
Inoue M.,
Saito J.,
Sasagawa T.,
Ueda G.,
Tanizawa O.
Publication year - 1992
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(92)90972-l
Subject(s) - polymerase chain reaction , human papillomavirus , cervical carcinoma , virology , real time polymerase chain reaction , medicine , pathology , biology , cervical cancer , cancer , gene , genetics
We applied the polymerase chain reaction (PCR) to detect HPV 16 and 18 in cytological samples obtained from the uterine cervices of Japanese women. HPV infection was detected in 17 (25%) of 67 with CIN and 11 (37%) of 30 with cervical carcinoma. It is notable that 11 (16%) of 69 women with normal cervices were infected with either HPV 16 or 18. The polymerase chain reaction is sensitive and useful for epidemiological studies.