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Plasminogen activators and inhibitors in normal late pregnancy, postpartum and in the postnatal period
Author(s) -
Koh C.L.S.,
Viegas O.A.C.,
Yuen R.,
Chua S.E.,
Ng B.L.,
Ratnam S.S.
Publication year - 1992
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(92)90723-v
Subject(s) - medicine , pregnancy , plasminogen activator , postpartum period , urokinase , tissue plasminogen activator , endocrinology , biology , genetics
Tissue plasminogen activator (t‐PA), urokinase plasminogen activator (u‐PA) and plasminogen activator inhibitors (PAI) are elevated in late pregnancy with t‐PA and u‐PA remaining so at 6 weeks postnatal. PAI‐2 remains at postpartum but was absent by 6 weeks postnatal unlike PAI activity which was absent at postpartum and returned to nonpregnant level at postnatal. The potential fibrinolytic response to stress is much reduced in pregnancy thus increasing the risk of thromboembolism.