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Endometrial lesions in patients undergoing tamoxifen therapy
Author(s) -
De Muylder X.,
Neven P.,
De Somer M.,
Van Belle Y.,
Vanderick G.,
De Muylder E.
Publication year - 1991
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(91)90767-y
Subject(s) - medicine , tamoxifen , endometrial polyp , hysteroscopy , endometrium , endometrial cancer , adjuvant therapy , endometrial hyperplasia , breast cancer , gynecology , oncology , urology , cancer
Abstract Forty‐six nonhysterectomized women treated with tamoxifen during 6–36 months as adjuvant therapy for breast cancer underwent a hysteroscopy to assess the endometrial effects of this drug. Whereas the endometrium was normal among 23 patients, 13 presented with endometrial polyps, 8 with hyperplasia and 2 with adenocarcinoma. The rate of endometrial lesions was directly related to the cumulative dose of tamoxifen but it was not statistically different among patients receiving progestational therapy compared to patients who did not receive this therapy.