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Prognostic factors in invasive squamous cell carcinoma of the vulva
Author(s) -
Frankman O.,
Kabulski Z.,
Nilsson B.,
Silfverswärd C.
Publication year - 1991
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(91)90717-j
Subject(s) - vulva , grading (engineering) , malignancy , basal cell , medicine , oncology , stage (stratigraphy) , prognostic variable , survival rate , pathology , overall survival , biology , ecology , paleontology
Histological malignancy grading and its correlation to prognosis were retrospectively investigated in 303 cases of squamous cell carcinoma of the vulva. A scoring system based on several variables is suggested. The scores and the individual histological variables were tested along with clinical factors with a view to predicting survival. Various histological variables including mode of invasion, depth of invasion and nuclear polymorphism, as well as the sum of the scores were good predictors of survival. The study revealed a significantly better survival rate in stage III if no metastates were suspected. An age factor was also found showing that cancer of the vulva has a worse prognosis in older women.