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Cytohistology, colposcopy and in situ hybridization in cervical preneoplastic lesions: A correlative study
Author(s) -
Pasetto N.,
Piccione E.,
Mantenuto L.,
Sesti F.
Publication year - 1991
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(91)90665-r
Subject(s) - colposcopy , medicine , in situ hybridization , pathology , in situ , hybridization probe , cytology , dna , cervical cancer , cancer , biology , gene , genetics , physics , meteorology , gene expression
Formalin‐fixed, paraffin‐embedded cervical tissues from 106 patients which exhibited a colposcopically atypical transformation zone, were examined for the presence of HPV DNA by in situ hybridization using biotin‐labeled HPV 6/11 and 16/18 DNA probes. From the comparative study between histologic, cytologic, colposcopic findings and virologic results it is confirmed that HPV 6/11 DNA is detected more frequently in the less severe lesions, whereas HPV 16/18 DNA is predominantly found in the most severe dysplastic lesions.