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Fructosamine as a screening‐test for gestational diabetes mellitus: a reappraisal
Author(s) -
Nasrat H.A.,
Ajabnoor M.A.,
Ardawi M.S.M.
Publication year - 1991
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(91)90534-c
Subject(s) - fructosamine , medicine , gestational diabetes , diabetes mellitus , gestation , pregnancy , endocrinology , hemoglobin , obstetrics , biology , genetics
Fructosamine, glycosylated hemoglobin (HbA Ic ) and serum total proteins were measured in normal nondiabetic pregnant women (n = 170) at three stages of pregnancy (14–18, 24–28, and 32–40 weeks of gestation). No significant correlation was found between fructosamine and either HbA Ic or total plasma proteins. Only early in pregnancy (< 20 weeks of gestation) was a correlation found between fructosamine and fasting blood glucose (r = 0.40, P < 0.05). There was also no correlation between either tests (i.e. fructosamine and HbA Ic ) and fetal birthweight. The value of fructosamine measurement in the detection of diabetes in pregnancy was further tested in a group of high‐risk patients (n = 98) for developing carbohydrate intolerance. It is concluded that fructosamine has limited value as a screening test for gestational diabetes mellitus, particularly for the mild form of the glucose intolerance.