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Basic and clinical aspects of GnRH‐agonists in reproduction
Author(s) -
Schmutzler R.K.,
Diedrich K.
Publication year - 1990
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(90)90108-w
Subject(s) - medicine , endometriosis , in vitro fertilisation , pregnancy , reproduction , agonist , human reproduction , pregnancy rate , uterus , physiology , gynecology , receptor , anatomy , biology , ecology , genetics
Within recent years GnRH agonists have gained increasing importance in the treatment of reproductive failure. Their use as a pretreatment for in vitro fertilization increases the pregnancy rate at least under certain conditions. In cases of endometriosis and uterus myomatosus, GnRH agonists achieve high remission rates and may avoid or at least postpone the need for surgical intervention. The physiological basis and current clinical strategies are discussed.