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Effects of oral contraceptive pills on serum lipoproteins and triglycerides
Author(s) -
Towobola O.A.,
Otubu J.A.M.,
Uguru V.E.
Publication year - 1990
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(90)90011-9
Subject(s) - medicine , pill , hormonal contraception , ethinylestradiol , blood lipids , population , high density lipoprotein , cholesterol , hormone , endocrinology , triglyceride , levonorgestrel , family planning , research methodology , pharmacology , environmental health
Possible effects of a combined oral contraceptive (femenal) on blood triglycerides and high‐density‐lipoprotein‐cholesterol (HDL‐Chol) were studied in 25 women who had opted for hormonal contraception. Total serum triglycerides of 64.60 ± 12.39 mg/dl (mean ± SD) obtained prior to the commencement of hormonal contraception, did not reveal any statistical difference from the value of 65.49 ± 7.96 mg/dl obtained after 9 months contraception. Similarly, precontraception HDL‐Chol value of 58.05 ± 6.58 mg/dl was also not statistically different from the treatment value of 58.82 ± 5.42 mg/dl. Regression analysis of the values between control (precontraception) and treatment (9 months contraception) showed high correlation coefficients: (1) serum triglycerides, R 2 = 0.5201; P < 0.001; (2) serum HDL‐Chol, R 2 = 0.6590; P < 0.001. Both the mean body weight and blood pressure of the study subjects remained unchanged after 9 months continuous use of femenal for contraception.