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Cervical ripening with intravaginal prostaglandin E 2 gel
Author(s) -
Curet L.B.,
Gauger L.J.
Publication year - 1989
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(89)90722-4
Subject(s) - placebo , prostaglandin e2 , prostaglandin , medicine , intravaginal administration , prostaglandin e , randomized controlled trial , anesthesia , surgery , vagina , alternative medicine , pathology
Fifty‐four patients were randomized in a double blind fashion into either a placebo group or a group treated with a 3 mg dose of an intravaginal prostaglandin E 2 gel. The group receiving the prostaglandin E 2 gel had a mean change in cervical score of 2.7 while the patients in the placebo group had no significant change. Even though a significantly higher number of patients in the prostaglandin group went into spontaneous labor, the incidence of cesarean section was not different between the two groups. Upon comparing the conflicting reports of various studies on the subject, it is concluded that the method of product preparation, particularly the source of prostaglandin E 2 utilized and the choice of drug vehicle, may be important variables in determining treatment success, as measured in terms of decreased cesarean section rate.