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Prostaglandin E 2 induction of abortion and fetal demise
Author(s) -
Wiley T.L.,
Poole C.P.,
Gookin K.S.,
Wiser W.L.,
Morrison J.C.
Publication year - 1989
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(89)90478-5
Subject(s) - medicine , demise , abortion , labor induction , obstetrics , prostaglandin , prostaglandin f , dinoprostone , prostaglandin e , prostaglandin analogue , prostaglandin e2 , induction of labor , pregnancy , gynecology , oxytocin , genetics , political science , law , biology
Prostaglandin E 2 (PGE 2 ) suppositories have been shown to be active contractile agents and are effective in uterine evacuation for mid‐trimester abortion or fetal demise. In this study, 85 patients were treated with vaginal PGE 2 suppositories. When laminaria were used in patients with closed cervices, and compared to those who had minimal cervical dilatation, there was no difference in the time from induction to expulsion. Ninety‐three percent of the 85 patients aborted successfully within 24 h. In each of the seven “failures”, three or less suppositories were used prior to a dilatation and evacuation procedure. In this study, 81% of the abortions were complete, and in one‐third of the remaining patients dilatation and curettage was performed just after delivery of the fetus. The incidence of minor side‐effects ranged from 12 to 21%, and there were no major complications. It is concluded that the use of vaginal prostaglandin E 2 suppositories for induction of mid‐trimester abortion or fetal demise in the third trimester is safe and effective.