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Sulbactam/ampicillin versus cefotetan in the treatment of obstetric and gynecologic infections
Author(s) -
Scalambrino S.,
Mangioni C.,
Milani R.,
Regallo M.,
Norchi S.,
Negri L.,
Carrera S.,
Vigano E.F.,
Ruffilli M.P.,
Canale M.P.
Publication year - 1989
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(89)90088-x
Subject(s) - medicine , cefotetan , sulbactam , ampicillin , discontinuation , antibiotics , surgery , antibiotic resistance , imipenem , microbiology and biotechnology , biology
In an open, randomized clinical study, the safety and efficacy of sulbactam/ampicillin was compared to that of cefotetan in 95 hospital patients with gynecologic or obstetric infections. Sulbactam/ampicillin (1 g:2 g), was administered intravenously every 8 h to 46 patients, and cefotetan (2 g) was administered intravenously every 12 h to 49 patients. All 23 patients with obstetric infections and 18 of the 23 patients with gynecologic infections treated with sulbactam/ampicillin were evaluated as cured. All 21 patients with obstetric infections and 23 of the 28 patients with gynecologic infections treated with cefotetan were evaluated as cured. No side effects requiring discontinuation of therapy or reduction of the dose administered, were observed.