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Sequential radiation changes in cytology of vaginal smears in carcinoma of cervix uteri during radiotherapy
Author(s) -
Gupta S.,
Mukherjee K.,
Gupta Y.N.,
Kumar M.
Publication year - 1987
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(87)90290-6
Subject(s) - medicine , cervix , radiation therapy , vaginal smear , adenocarcinoma , carcinoma , cancer , cervical cancer , vaginal cancer , cytology , vagina , gynecology , pathology , surgery , estrous cycle
The study deals with acute/immediate radiation changes in 2020 sequential vaginal smears in 101 patients of carcinoma of the cervix uteri, 97 were of squamous cell carcinoma and 4 of adenocarcinoma. The smears were collected after 12–14 days, 15–24 days and 25 days to 6 weeks following radiotherapy. The pretreatment vaginal smears were collected and examined for percentage of cancer cells. Subsequent smears were studied for radiation changes in benign and malignant cells, such as cell size, vacuolation of cytoplasm, multinucleation and nuclear changes, etc. A gradual and linear decline in cancer cells was observed until the end of therapy; 41.6% of patients had less than 10% cancer cells within 12–14 days of therapy, 63.4% of patients between 15 and 24 days and 74.6% after 25 days to 6 weeks following radiation. Eighty three percent of the patients attained zero level at the end of therapy.