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Plasma fibronectin levels in normal pregnancy and pre‐eclampsia: A preliminary report
Author(s) -
Thurnau G.R.,
Morgan M.A.,
Brubaker D.,
Romine M.,
Blackshaw C.,
Fishburne J.I.,
Fishburne I.
Publication year - 1987
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(87)90059-2
Subject(s) - fibronectin , eclampsia , medicine , extracellular matrix , nephelometry , preeclampsia , basement membrane , endocrinology , pregnancy , andrology , immunology , pathology , biology , biochemistry , antibody , genetics
Fibronectin, a major component of the extracellular matrix and basement membranes throughout the body, is thought to maintain the integrity of both the reticulo‐endothelial system and microvasculature. In this study, plasma fibronectin levels were assayed by nephelometry in nine pre‐eclamptic gravid women, nine normotensive gravid women and ten non‐gravid women. The mean plasma fibronectin level (±S.E.M.) in pre‐eclamptic gravidas (1687 ± 101 μg/ml) is significantly higher than that of either normotensive gravidae (1129 ± 99 μg/ml) or non‐gravid women (897 ± 60 μg/ml). Although the mechanism for elevated levels of plasma fibronectin in patients with pre‐eclampsia is not clear, it may serve as an early biochemical marker for this disorder.