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Neutral mucosubstances as a prognostic indicator in serous and endometrioid carcinomas of the ovary. A morphometrical analysis of saliva‐periodic acid‐Schiff stain
Author(s) -
Aalto M.L.
Publication year - 1986
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(86)90038-x
Subject(s) - serous fluid , medicine , periodic acid–schiff stain , ovary , serous carcinoma , staining , pathology , stain , h&e stain , carcinoma , gastroenterology , cancer , ovarian cancer
Forty‐four serous and 17 endometrioid carcinomas of the ovary were classified on hematoxylin‐eosin stained tissue sections using the criteria of World Health Organization (WHO). The amount of saliva‐periodic acid‐Schiff (SPAS) staining positivity, indicating presence of neutral mucosubstances, was quantitated morphometrically and compared with survival of the patients. The 5‐year survival of patients who had SPAS positive serous carcinoma was 36% whereas that of patients with SPAS negative serous carcinomas was only 7%. Among the patients who had endometrioid carcinoma showing SPAS positivity over the median, the 5‐year survival was 47%. All patients with SPAS positivity less than the median had died in 3 years after the diagnosis. The differences in survivals were statistically significant (P < 0.001). This study shows that neutral mucosubstances as quantitated morphometrically is a good prognostic indicator of serous and endometrioid carcinomas of the ovary.