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Broad spectrum antibiotics as short term prophylaxis for elective abdominal hysterectomy: Comparison of mezlocillin, cefazolin and placebo
Author(s) -
Hakim M.,
Gonen R.,
Levitan Z.,
Sharf M.
Publication year - 1986
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(86)90011-1
Subject(s) - medicine , mezlocillin , cefazolin , broad spectrum , abdominal hysterectomy , hysterectomy , placebo , antibiotics , surgery , genetics , alternative medicine , pathology , bacteria , microbiology and biotechnology , pseudomonas aeruginosa , biology , piperacillin , chemistry , combinatorial chemistry
A prospective randomized placebo controlled double‐blind study was conducted in order to evaluate the effect of short term perioperative antibiotic prophylaxis on patients undergoing elective abdominal hysterectomy. Fifty‐two patients received 3 doses of 0.5 g cefazolin, 54 patients received 3 doses of 1 g mezlocillin and 53 patients received placebo. Postoperative infectious morbidity and the rate of pelvic cellulitis were significantly lower in either antibiotic group in comparison to the placebo group, but neither drug proved to be superior in this respect. The fever index was significantly lower in the mezlocillin group in comparison to both cefazolin and placebo groups. It was thus concluded that antibiotic prophylaxis has a beneficial effect on patients undergoing abdominal hysterectomy and both drugs ‐ cefazolin and mezlocillin ‐ seem to be equally effective.