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Luteal phase defects in repeated abortion
Author(s) -
Vanrell Juan A.,
Balasch Juan
Publication year - 1986
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(86)90004-4
Subject(s) - luteal phase , medicine , endometrial biopsy , basal body temperature , infertility , endometrium , prolactin , basal (medicine) , hormone , menstrual cycle , gynecology , in utero , pregnancy , endocrinology , fetus , diabetes mellitus , biology , genetics
Fifty women with 2 or more previous first‐trimester abortions and 300 infertile patients underwent a luteal phase evaluation by basal body temperature, plasma progesterone, estradiol and prolactin determination, and endometrial biopsy (repeated in a later cycle when the first was defective). An endometrial luteal phase deficiency was detected in 15 (30%) of aborting patients. In 13 (26%) of these women the endometrial defect was associated to normal hormonal levels. This condition was only present in 36 (12%) of the infertility cases (P < 0.01). We conclude that the possible etiologic role of luteal phase defects in repeated abortion, is by a secretory insufficiency in the endometrial pattern despite normal plasma hormonal levels.