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Influence of different prostaglandin applications on cervical rheology
Author(s) -
Spätling Lugwig,
Neuman Michael R.,
Huch Renate,
Huch Albert
Publication year - 1985
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(85)90145-6
Subject(s) - medicine , cervical canal , cervix , vagina , cervical insufficiency , prostaglandin e2 , prostaglandin , pregnancy , surgery , cancer , biology , genetics
The softening effect of prostaglandin (PG) on cervical tissue prior to elective pregnancy termination is quantified by a new technique for the measurement of the elastance and relaxation of the cervix. The method is based on the pressure‐volume relation of a compliant balloon placed in the cervical canal. These properties have been measured before and after different applications of prostaglandins in 58 patients electively terminating pregnancy. Application techniques used included high pressure jet application of PGE 2 into the tissue of the portio uteri and the internal cervical os (120 μg), PGE 2 and PGF 2α in Tylose gel (100 μg/0.5 ml); PGE 2 as an intracervical tablet (150 μg) and PGE 2 oral tablets placed into the posterior fornix of the vagina. Significant changes in cervical elastance were seen with the intracervically applied PGE 2 in Tylose gel and the vaginally applied PGE 2 tablets. The intracervically applied PGE 2 gel also gave significant changes in cervical relaxation. No side effects other than mild cramping (2 patients) were seen with any of the applications in this study.