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Congenital adrenal hyperlasia and luteal dysfunction
Author(s) -
Villanueva A.L.,
Rebar R.W.
Publication year - 1985
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(85)90067-0
Subject(s) - luteal phase , medicine , androgen excess , infertility , pregnancy , endocrinology , androgen , steroid , adrenal function , physiology , follicular phase , hormone , biology , insulin resistance , polycystic ovary , insulin , genetics
A case of 21‐hydroxylase deficiency diagnosed and first treated at the age of 3 years is presented. Although pubertal development was delayed, full reproductive function was attained, with menses occurring at 14–33‐day intervals. Infertility evaluation at age 20 revealed elevated 17‐hydroxyprogesterone (17Po) and androgen concentrations and reduced luteal phase progesterone levels consistent with inadequate luteal function. This was corrected with additional cortico‐steroid replacement. Normal pregnancy and delivery followed.