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Effect of oral contraception on serum bile acid
Author(s) -
Shaaban Mamdouh M.,
Ghaneimah Sharaf A.,
Mohamed Mohamed A.,
AbdelChani Soad,
Mostafa Sayed A.
Publication year - 1984
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(84)90023-7
Subject(s) - medicine , bile acid , levonorgestrel , bilirubin , alkaline phosphatase , endocrinology , liver function tests , liver function , albumin , immunoassay , gastroenterology , population , enzyme , family planning , immunology , research methodology , biochemistry , antibody , chemistry , environmental health
Eighteen normal women, 20 with active urinary schistosomiasis, and 25 with past histories of viral hepatitis were given a contraceptive pill containing 0.05 mg ethinyl estradiol and 0.5 mg levonorgestrel for six consecutive cycles. Serum bile acid levels were measured by enzyme immunoassay method before and after 3 and 6 months of use. Simultaneously, conventional liver function tests (serum bilirubin, transaminases, alkaline phosphatase and albumin) were done. Serum bile acid concentration was not significantly changed by the contraceptive use in any group. The concentration of cholylglycine (the main bile acid measured) did not correlate with the values of any of the other tests. Pretreatment values of serum cholylglycine were significantly lower in the past‐hepatitis group. The difference was maintained during treatment.