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Contractile responses of uterine smooth muscle to acetylcholine and marihuana extract
Author(s) -
Murthy N.V.A.,
Melville G.N.,
Wynter Hugh H.
Publication year - 1983
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(83)90084-x
Subject(s) - ergometrine , medicine , acetylcholine , propranolol , endocrinology , atropine , uterus , uterine contraction , pharmacology
Marihuana extract (ME) is known to influence smooth muscle activity. This study was designed to investigate the effect of crude ME on rat uterine muscle and to explain the mechanism of action using antagonists such as atropine, ergometrine and propranolol. The contractions and the electrical activity were recorded on isolated superfused rat uteri. It is speculated that ME by its uterine stimulatory action compromise uterine blood and may affect oxygen/nutrient transfer. The implication of this to the fetus is discussed.