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Fetal pulmonary maturity: Relationship between optical density (650 nm) to the lecithin/sphingomyelin ratio and phosphatidylglycerol in amniotic fluid
Author(s) -
Moodley Sangithan,
Liu James H.,
Cherkis Richard C.,
Miller Richard K.,
Allen Merritt T.,
Whalen Lorraine E.
Publication year - 1983
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(83)90080-2
Subject(s) - amniotic fluid , medicine , amniocentesis , phosphatidylglycerol , lecithin , obstetrics , respiratory distress , andrology , population , gestation , fetus , gastroenterology , pregnancy , prenatal diagnosis , chromatography , phospholipid , surgery , biology , chemistry , biochemistry , genetics , environmental health , membrane , phosphatidylcholine
An optical density value ⩾0.15 at A 650 nm of amniotic fluid obtained through transabdominal amniocentesis from a high risk obstetrical population, which excluded diabetes mellitus, isoimmunization, and amniotic fluid infection, correlated 98.6% with a mature lecithin to sphingomyelin ratio (L/S) ⩾ 2.0% and 41.6% with the presence of phosphatidylglycerol (PG). The corresponding false positive rates were 1.4% and 16.8%, respectively. In 30 infants delivered within 48 h of testing, A 650 nm ⩾0.15 correlated 100% with absence of respiratory distress syndrome. A 650 nm is not recommended for Rhesus immunized gestations, diabetic pregnancies and amniotic fluid infection due to a high false positive rate with A 650 nm compared to L/S and PG.