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Methoxyflurane hepatitis: Two cases following obstetric analgesia
Author(s) -
Delia Julian E.,
Maxson Wayne S.,
Breen James L.
Publication year - 1983
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(83)90076-0
Subject(s) - methoxyflurane , medicine , toxic hepatitis , hepatitis , hepatotoxin , anesthesia , halothane , toxicity
Abstract Methoxyflurane is utilized in obstetrics for analgesia during labor. It has been recognized as an unpredictable hepatotoxin. Although hepatitis has been seen after its use in anesthesia, only one case of hepatitis has been reported after its use for analgesia in labor. Two more cases of hepatitis following methoxyflurane analgesia are reported. Direct toxic effects of its metabolites and host idiosyncracy may underlie the hepatic injury from methoxyflurane.