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A comparison of serum free estriol with spontaneous urine total estrogen and estrogen/creatinine ratio
Author(s) -
Dawson Earl B.,
Simmons Joseph E.,
Nagamani Manubai
Publication year - 1983
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(83)90003-6
Subject(s) - estriol , urine , estrogen , creatinine , endocrinology , radioimmunoassay , medicine , pregnancy , chemistry , biology , genetics
A mathematical comparison was made between the serum free estriol levels, the urine total estrogen, and the total estrogen/creatinine ratio in 83 pregnant women during the last trimester of pregnancy. The blood serum and spontaneous urine samples were obtained simultaneously, and each woman was sampled once. The serum estriol was measured by radioimmunoassay and the urine estrogen levels measured by the aqueous fluorometric Kober technique. The group averages of the three different measurements paralleled each other throughout the third trimester. Linear regression and correlation studies of the measured levels for each subject by the different methods were statistically significant ( P ≤ 0.0001). The correlation factor between serum free estriol and spontaneous urine total estrogen was +0.5991, and between serum free estriol and the spontaneous urine total estrogen/creatinine ratio was +0.8086. The very high correlation between the two urine and the serum method suggest that spontaneous urine samples may be used to measure estrogen changes during pregnancy.