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A new method for the induction of therapeutic amenorrhea: Low dose endometrial afterloading irradiation. Clinical and hormonal studies
Author(s) -
Grönroos M.,
Turunen S.,
Salmi T.,
Raekallio J.,
Ruotsalainen P.
Publication year - 1982
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(82)90060-1
Subject(s) - medicine , amenorrhea , ovulation , endometrium , hormone , ovulation induction , irradiation , endocrine system , physiology , plasma levels , gynecology , in utero , pregnancy , biology , genetics , physics , nuclear physics , fetus
The authors present a new method for the induction of therapeutic amenorrhea: low dose endometrial afterloading irradiation. The problem with this method has been how to inactivate the endometrium while maintaining the physiological function of the ovaries. In 5/29 young patients regular or irregular bleedings occurred after an endometrial dose of 11 ± 1 Gy. These subjects were given a repeat low dose intrauterine irradiation. Thereafter no bleedings were found in four out of five patients. Two to 9 years after the repeat irradiation the plasma levels of E 2 , E 2 . FSH and LH corresponded closely to those of healthy women in reproductive age in three out of five patients; some high plasma P levels indicated ovulation. In two patients the E 1 , E 2 and P values were more likely postmenopausal but, on the other hand, FSH and LH values reproductive ones. The endocrinological studies after one irradiation [5] and the medico‐legal [15] and neuropsychiatric [17] aspects relevant to the method are presented elsewhere.