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Evaluation of cefoxitin prophylaxis for cesarean section
Author(s) -
Dillon William P.,
Seigel Mark S.,
Lele Amol S.,
O'Leary James A.
Publication year - 1981
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(81)90052-7
Subject(s) - cefoxitin , medicine , placebo , regimen , surgery , anesthesia , bacteria , genetics , alternative medicine , pathology , biology , staphylococcus aureus
Prophylactic cefoxitin was evaluated in 101 patients undergoing cesarean section. A three‐dose regimen of either cefoxitin or placebo was administered randomly in a double‐blind manner, 46 patients receiving cefoxitin and 55 placebo, with the first dose given after the cord was clamped. In the placebo group, 29% of the patients developed pelvic or wound infection, compared to 4% in the cefoxitin group (P < 0.003). No patient required re‐operation, re‐admission, or had a life threatening infection. Ten risk factors for infection were analyzed to help ascertain which patients would benefit from prophylaxis. Cefoxitin, with a broad spectrum of aerobic and anaerobic coverage, was found to be an effective and safe prophylactic agent when given to all patients undergoing cesarean section.