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Feedback effect of estradiol on follicle‐stimulating hormone and prolactin secretion during the puerperium
Author(s) -
Canales Elías S.,
Fonseca M.E.,
Mason Macrina,
Zárate Arturo
Publication year - 1981
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/0020-7292(81)90043-6
Subject(s) - prolactin , endocrinology , medicine , estrogen , follicle stimulating hormone , secretion , estradiol benzoate , lactation , hormone , postpartum period , prolactin cell , ovariectomized rat , pregnancy , luteinizing hormone , biology , genetics
Injections of 3 mg of estradiol benzoate were given to seven lactating women during the second and third weeks postpartum to study its effects on secretion of follicle‐stimulating hormone (FSH) and prolactin during the subsequent 4 days. Administration of estradiol during the second week postpartum had no effect on serum levels of FSH and prolactin, however, 1 week later estradiol injection elicited a double effect: FSH levels decreased and prolactin concentrations increased. Early lactation seems to abolish the estrogen induced positive feedback effect on pituitary gonadotropin secretion. The negative effect of estrogen on FSH secretion and the positive effect on prolactin release became evident by the third week postpartum.