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M‐caveolin, a muscle‐specific caveolin‐related protein
Author(s) -
Way Michael,
Parton Robert G.
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)82884-5
Subject(s) - caveolae , caveolin 3 , caveolin , caveolin 1 , myogenesis , microbiology and biotechnology , myocyte , chemistry , biology , signal transduction
Caveolae, small invaginations of the plasma membrane, are a characteristic feature of many mammalian cells. The best‐characterised caveolar protein is the integral membrane protein, VIP21‐caveolin. We now describe a novel homologue of VIP21‐caveolin, M‐caveolin, which is expressed exclusively in muscle. M‐caveolin was shown to be expressed in differentiated myotubes but not myoblasts. Epitope‐tagged M‐caveolin expressed in non‐muscle cells was targetted to surface caveolae where it colocalized with endogenous VIP21‐caveolin. M‐caveolin may play a specialised role in the caveolae of muscle cells.