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Genetic diversity of flagellins of Pseudomonas aeruginosa
Author(s) -
Spangenberg Claudia,
Heuer Thomas,
Bürger Christiane,
Tümmler Burkhard
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)01099-x
Subject(s) - flagellin , pseudomonas aeruginosa , biology , genetics , homology (biology) , gene , virulence , locus (genetics) , genome , nucleic acid sequence , bacteria
Physical genome analysis of the virulence‐associated fliC locus in 20 Pseudomonas aeruginosa strains by mapping and sequencing revealed groups of heterologous a‐type (1164 bp; 1185 bp) and highly conserved b‐type (1467 bp) flagellin genes. Whereas only two synonymous nucleotide substitutions were detected in eight b‐type fliC sequences, the 12 a‐type sequences exhibited 57 nucleotide substitutions, of which 39 occurred within a variable central region. Although a‐type and b‐type flagellins differ by 35% in their primary structure, they share strong homology in their predicted features, implying that the polymorphic proteins fold into similar structures during polymerization of the flagella.