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A systemic antiviral resistance‐inducing protein isolated from Clerodendrum inerme Gaertn. is a polynucleotide:adenosine glycosidase (ribosome‐inactivating protein)
Author(s) -
Olivieri Fabiola,
Prasad Vivek,
Valbonesi Paola,
Srivastava Shalini,
Ghosal-Chowdhury Papiya,
Barbieri Luigi,
Bolognesi Andrea,
Stirpe Fiorenzo
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)01089-7
Subject(s) - ribosome inactivating protein , polynucleotide , ribosome , antiviral protein , protein biosynthesis , biology , adenosine , rna , biochemistry , dna , chemistry , microbiology and biotechnology , gene
Two systemic antiviral resistance‐inducing proteins, CIP‐29 and CIP‐34, isolated from Clerodendrum inerme Gaertn. leaves, were tested for ribosome‐inactivating properties. It was found that CIP‐29 has the characteristics of a polynucleotide: adenosine glycosidase (ribosome‐inactivating protein), in that it inhibits protein synthesis both in cell‐free systems and, at higher concentrations, in cells, and releases adenine from ribosomes, RNA, poly(A) and DNA. As compared with other known RIPs, CIP‐29 deadenylates DNA at a high rate, and induces systemic antiviral resistance in susceptible plants.