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The influence of sub‐optimal protein nutrition on insulin hypersecretion evoked by high‐energy/high‐fat feeding in rats
Author(s) -
Holness Mark J.
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)01067-8
Subject(s) - medicine , endocrinology , insulin , endocrine system , biology , insulin resistance , pancreas , low protein diet , secretion , pancreatic hormone , carbohydrate metabolism , hormone
Low (8%) protein feeding during pregnancy impairs the functional development of the fetal endocrine pancreas. Continued low‐protein feeding post‐natally decreases pancreatic insulin content and secretion, whereas transfer to standard diet evoked β‐cell recuperation. Glucose‐stimulated insulin secretion (GSIS) and insulin action were examined in vivo at 28 days after transfer from 8% protein diet to a high‐energy/high‐fat/standard (20%)‐protein diet (HEF diet). HEF feeding dramatically enhanced GSIS after intravenous glucose in control rats, but not in rats previously maintained on the low‐protein diet. However, glucose disappearance after intravenous glucose, and glucose production and whole‐body glucose disposal during euglycaemic‐hyperinsulinaemic clamps were unaffected by prior protein malnutrition. In conclusion, impaired insulin secretion after protein malnutrition is exacerbated by high‐energy/high‐fat feeding, but this response is not linked to enhanced whole‐body insulin resistance.