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Cell surface receptor directed targeting of toxin to human malaria parasite, Plasmodium falciparum
Author(s) -
Surolia Namita,
Misquith Sandra
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)01065-4
Subject(s) - plasmodium falciparum , malaria , parasite hosting , virology , toxin , receptor , biology , microbiology and biotechnology , immunology , biochemistry , world wide web , computer science
Gelonin (a toxin and type II ribosome inactivating protein) when linked to human transferrin can be targeted to Plasmodium falciparum . The transferrin toxin conjugate is significantly toxic to parasite growth and is 25 times more potent than toxin alone in inhibiting parasite protein synthesis. The mechanism of its entry into the intraerythrocytic parasite is discussed.