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Regulation of Mg 2+ homeostasis by insulin in perfused rat livers and isolated hepatocytes
Author(s) -
Keenan Donald,
Romani Andrea,
Scarpa Antonio
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)01051-4
Subject(s) - homeostasis , chemistry , insulin , medicine , endocrinology , glucose homeostasis , hepatocyte , microbiology and biotechnology , biochemistry , biology , insulin resistance , in vitro
Several recent studies demonstrate that adrenergic receptor stimulation evokes marked changes in Mg 2+ homeostasis. As insulin counter‐regulates many of the metabolic consequences of adrenergic receptor stimulation, we evaluated the potential influence of insulin on Mg 2+ movements in response to adrenergic stimulation. The data demonstrate that insulin is able to block the Mg 2+ efflux from perfused rat livers stimulated by isoproterenol or 8‐Br‐cAMP, but has little or no effect on epinephrine or phenylephrine induced Mg 2+ efflux. Thus, evidence is provided demonstrating that there are redundant adrenergic pathways regulating Mg 2+ efflux from liver tissue. One of these pathways, the β‐adrenergic component, is selectively blocked by insulin. Furthermore, these findings may provide a cellular explanation for hypomagnesemia associated with diabetes.