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Cloning and expression of a novel type (III) of human γ‐glutamyltransferase truncated mRNA
Author(s) -
Leh Hervé,
Courtay Céline,
Gerardin Philippe,
Wellman Maria,
Siest Gérard,
Visvikis Athanase
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00965-9
Subject(s) - cloning (programming) , messenger rna , microbiology and biotechnology , chemistry , biology , genetics , gene , computer science , programming language
We report the characterization of a novel human γ‐glutamyltransferase mRNA type. This type III mRNA differs from type I and type II mRNAs previously described by several point mutations and the presence of an unspliced 81 bp intron in the open reading frame. Further, type III mRNAs are truncated ones and are tissue and pathology specifically expressed. In fact, type III mRNAs are present in human placenta, sigmoid, lung and in 50% of acute lymphoblastic leukemia blood cells but they are never found in healthy lymphocytes.