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Differential effects of Th1 and Th2 derived cytokines on NGF synthesis by mouse astrocytes
Author(s) -
Brodie Chaya
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00911-8
Subject(s) - secretion , cytokine , neurotrophic factors , neurotrophin , nerve growth factor , endocrinology , tumor necrosis factor alpha , medicine , chemistry , inflammation , biology , immunology , receptor
During the course of brain injury and inflammation there is an increased secretion of neurotrophic substances by astrocytes. We have examined the effect of the Th2‐derived cytokine IL‐10 and the Th1‐derived cytokines Il‐2 and IFN‐γ on the secretion of NGF by mouse astrocytes. IL‐10 induced a dose‐dependent increase in NGF secretion which was blocked by anti‐IL‐10 antibody. In contrast, the Th1‐derived cytokines IFN‐γ and IL‐2 did not induce NGF synthesis. Moreover, INF‐γ completely inhibited the increase in NGF secretion induced by IL‐10 whereas it had no effect on the induction of NGF by TNF‐α. These results indicate that IL‐10 similarly to other Th2‐derived cytokines may provide a neurotrophic support to injured neurons via the induction of NGF synthesis, whereas the Th1‐derived cytokine IFN‐γ antagonizes this effect.