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Molecular cloning, functional expression and chromosomal localization of a human homolog of the cyclic nucleotide‐gated ion channel of retinal cone photoreceptors
Author(s) -
Yu Wei-Ping,
Grunwald Maria E.,
Yau King-Wai
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00889-7
Subject(s) - cyclic nucleotide gated ion channel , ion channel , cloning (programming) , molecular cloning , biology , hek 293 cells , microbiology and biotechnology , retina , gene , genetics , chemistry , nucleotide , cyclic nucleotide , peptide sequence , receptor , neuroscience , computer science , programming language
We have cloned from human retina a cyclic nucleotide‐gated (CNG) ion channel that is distinct from the one found in rod photoreceptors. This channel protein is highly homologous to the CNG channel that recently has been cloned from bovine testis and kidney and has been shown to be present i retinal cone photoreceptors. When expressed in human embryonic kidney cells, the protein forms functional ion channels with properties broadly similar to those described for the cloned bovine channel. The gene for this channel resides on chromosome 2.