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IL4 and IL13 receptors share the γc chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells
Author(s) -
Rolling Christine,
Treton Dominique,
Pellegrini Sandra,
Galanaud Pierre,
Richard Yolande
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00835-6
Subject(s) - stat6 , stat5 , interleukin 4 , stat , interleukin 13 , microbiology and biotechnology , stat3 , chemistry , receptor , biology , signal transduction , cytokine , immunology , biochemistry
IL13 induces the same biological effects as IL4 in normal human B cells. We show that as in the IL4R complex, both IL4Rα and IL2Rγc are components of the IL13R and that both cytokines induced STAT6, STAT3 and STAT5 activation in B cells. In spite of this similar downstream signalling, IL4 and IL13 used a different set of Janus kinases: IL13 is unable to activate JAK1 and JAK3.