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Novel harmful effects of [60]fullerene on mouse embryos in vitro and in vivo
Author(s) -
Tsuchiya Toshie,
Oguri Ikuko,
Yamakoshi Yoko Nakajima,
Miyata Naoki
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00812-5
Subject(s) - in vivo , in vitro , embryo , intraperitoneal injection , chemistry , incubation , microbiology and biotechnology , andrology , pharmacology , biology , biochemistry , medicine
[60]Fullerene (C60) was solubilized with poly(vinylpyrrolidone) (PVP) in water, and the aqueous solution was applied to a mouse midbrain cell differentiation system. On incubation of C60 with various concentrations of PVP, cell differentiation and proliferation were potently inhibited, although weaker than the vehicle controls. C60 was clearly distributed into the yolk sac and embryos by intraperitoneal administration to pregnant mice at 50 mg/kg and had a harmful effect on both conceptuses by microscopical evaluation. This in vivo and in vitro action on embryogenesis is a novel and seriously harmful activity of C60.