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A novel leptin receptor isoform in rat
Author(s) -
Wang May-Yun,
Yan Ting Zhou,
Newgard Christopher B.,
Unger Roger H.
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00790-9
Subject(s) - gene isoform , leptin , medicine , endocrinology , receptor , leptin receptor , hypothalamus , biology , spleen , kidney , gene , chemistry , biochemistry , obesity
Five mouse and human leptin receptors (Ob‐R) have recently been identified, a long isoform (Ob‐Rb), preferentially expressed in hypothalamus, and 4 short isoforms, Ob‐Ra, Ob‐Rc, Ob‐Rd, and Ob‐Re. We have identified a new short isoform in the rat, r‐OB‐Rf, with 6 C‐terminal amino acids and a 3′ untranslated region without homology to other Ob‐R isoforms. Its higher expression in rat liver and spleen compared to brain, stomach, kidney, thymus, heart, lung and hypothalamus, contrasts with Ob‐Ra and Ob‐Rb homologues and raises possibilities of as yet unidentified roles for members of the growing Ob‐R gene family.