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Identification of a novel endogenous memory facilitating cyclic dipeptide cyclo‐prolylglycine in rat brain
Author(s) -
Gudasheva T.A,
Boyko S.S,
Akparov V.Kh,
Ostrovskaya R.U,
Skoldinov S.P,
Rozantsev G.G,
Voronina T.A,
Zherdev V.P,
Seredenin S.B
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00722-3
Subject(s) - dipeptide , endogeny , chemistry , high performance liquid chromatography , mass spectrometry , chromatography , peptide , biochemistry
Using high‐performance liquid chromatography, gas‐chromatography and chromato‐mass spectrometry methods a novel endogenous cyclic dipeptide cyclo‐prolylglycine was identified in rat brain. Its content according to gas chromatography is 2.8 ± 0.3 nmol/g wet brain. Synthetic cyclo‐prolylglycine has demonstrated antiamnesic activity in the passive avoidance test in rats at a dose of 0.1 mg/kg i.p. Cyclic dipeptide cyclo‐prolylglycine seems to be a memory facilitating substance and its presence in rat brain suggests the existence of a new mechanism of memory regulation.